Tesofensine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Te, Ns-2330
Summary
Tesofensine is a triple-monoamine reuptake inhibitor originally developed for neurodegenerative disorders but repurposed for obesity treatment. Clinical pharmacokinetics show an elimination half-life of ≈220 hours with an active N-desalkyl metabolite (NS2360) lasting ≈374 hours; steady-state is reached only after 4-5 weeks. Single overdoses can linger for over a week.
Dose Information
| ROA | Threshold |
|---|---|
| Oral | 0.05mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 2-4 hrs | 4-10 hrs | 12-24 hrs | 18.5-40 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate focus, mild euphoria and stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Tesofensine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Tesofensine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.05 Oral duration: onset 0.5-2h · come-up 2-4h · peak 4-10h · offset 12-24h · total 18.5-40h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Tesofensine? Let us know. Reports are reviewed by moderators — this is not posted publicly.