A very elusive cousin to LSD, methylisopropyllysergamide (MiPLA) was originally synthesized by Albert Hofmann, but never ended up becoming as popular among psychedelic users.
MiPLA
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Lamide
Summary
MiPLA is a research chemical with very limited history of human use and minimal scientific study of its pharmacology, metabolism, and toxicity. It is approximately two to three times less potent than LSD and has a notably shorter duration of around 4-6 hours. The substance is generally described as producing less anxiety and a lighter headspace compared to LSD, with more recreational and social characteristics.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-150ยตg | 150-200ยตg | 200-250ยตg | 300ยตg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-40 min | 45-90 min | 1-2 hrs | 1-2 hrs | 3.07-6.17 hrs |
Effect Profile
7 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
4.5
Moderate
4/10
Mild visuals, headspace, and body load
Visual Intensity
×3
5
color enhancement
pattern recognition enhancement
visual acuity enhancement
Headspace Depth
×3
5
conceptual thinking
emotion enhancement
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
4
nausea
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (lysergamide)
Reset
7โ14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 7 Erowid experience reports
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect, something witnessed, or "did not happen" count too). Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 8
85.7%
–
71.4%
–
71.4%
–
71.4%
–
71.4%
–
57.1%
–
57.1%
–
42.9%
–
Adverse Effects 2
42.9%
–
42.9%
–
Combinations
Cross-Check MiPLA with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 4 reports 3 positive 1 neutral visit
July 27th, 2019 : 1st trial of MiPLA (200ug), bought from a reputable canadian vendor. I recently tried MiPLA for the first time. The reviews and anecdotic reports on this molecule were sparse, but all positive; saying it was a lighter, milder type of "acid".
25 May 2018: 1st Trial of alleged 200 ฮผg MIPLA tabs from Poland Tripping well grounded This was a planned, much-anticipated first experience with MIPLA, a novel lysergamide. Novel to me certainly, with little hard documentation to go on. I had heard, on highest authority, MIPLA was a good one.
Setting: bedroom with s/o, watching television 8:13: 200ug MiPLA tab under the tongue, no taste, tab larger than most I've received 9:00 their definately is a hint of something coming on, colors are beginning to appear brighter, in better humor than usual, blankets feel extra soft.
Bluelight 1 thread 1 neutral visit
25 May 2018: 1st trial of alleged 200 ฮผg MIPLA tabs from Poland This was a planned, much-anticipated first experience with MIPLA, a novel lysergamide. Novel to me certainly, with little hard documentation to go on. I had heard, on highest authority, MIPLA was a good one. Atypically, I did not test this material.
Bluelight Reference Guide
Lysergamides The Big & Dandy MIPLA (Methylisopropyllysergamide) Thread
iupac = (8ฮฒ)-N-Isopropyl-N,6-dimethyl-9,10-didehydroergoline-8-carboxamide The production of this compound was hinted at by a very reputable source. There is next to nothing on this compound that I can find on the web, besides a single erowid article.
Read full thread on Bluelight โ
MiPLA's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes MiPLA, but its built-in data can be thinner than ours. Importing this file adds a separate "MiPLA (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
⬇ Download import file
Import this file as custom substances
and you get "MiPLA (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for MiPLA? Let us know. Reports are reviewed by moderators — this is not posted publicly.