Flumazenil
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 27 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- 27 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Anexate, Lanexat, Mazicon, Romazicon, Ro 15-1788
Summary
Flumazenil is the benzodiazepine antidote and can abruptly trigger withdrawal or seizures in dependent individuals. It should only be used with seizure management on standby and careful screening for mixed overdoses. Flumazenil competitively blocks the benzodiazepine site on the GABAA receptor.
Dose Information
| ROA | Threshold |
|---|---|
| Intravenous (Bolus) | 0.1mg |
| Intravenous Infusion (Resedation Prevention) | 0.1mg/h |
| Intranasal (Investigational / Pediatric) | 0.02mg/kg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Intravenous (Bolus)
Dose ladder — DrugsPROIntravenous Infusion (Resedation Prevention)
Dose ladder — DrugsPROIntranasal (Investigational / Pediatric)
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Intravenous (Bolus) | 1-2 min | 6-10 min | 1-2 hrs | 1.12-2.2 hrs |
| Intranasal (Investigational / Pediatric) | 5-8 min | 10-20 min | 1-2 hrs | 1.25-2.46 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Low anxiolysis and sedation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
- Anxiety or panic
Combinations
Cross-Check Flumazenil with another substanceHelpful Links
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Flumazenil Source: SubstanceSearch (substancesearch.com) Intravenous (Bolus) dose (mg): threshold 0.1 Intravenous Infusion (Resedation Prevention) dose (mg): threshold 0.1/h Intranasal (Investigational / Pediatric) dose (mg): threshold 0.02/kg Intravenous (Bolus) duration: onset 1-2m · peak 6-10m · offset 1-2h · total 1.12-2.2h · after-effects 6h Intravenous Infusion (Resedation Prevention) duration: onset <1-1m · offset 1h · after-effects 6h Intranasal (Investigational / Pediatric) duration: onset 5-8m · peak 10-20m · offset 1-2h · total 1.25-2.46h · after-effects 6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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