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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Cl-MAR Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4c-mar

    Stimulant Research-chemical

    Summary dose.wiki

    4-Cl-MAR is a novel halogenated aminorex derivative with virtually no human safety data. Halogenated aminorexes may share neurotoxicity concerns seen with halogenated amphetamines. Anecdotal reports suggest inconsistent batch potency and minimal euphoria at doses below 150 mg.

    Dose Information Drugs.Wiki

    Dose basis. Ranges are mostly from user reports; batches may vary widely in potency and may be misidentified. Start with an allergy test and titrate cautiously. Crystalline material may be hard on nasal mucosa; allergy test first (≤5–10 mg) and avoid repeated lines due to long action. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 40-80mg 80-150mg 150-200mg 200mg+
    Insufflated 10-25mg 25-50mg 50-80mg 80mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 1-2 hrs 2-4 hrs 4-6 hrs 6-24 hrs 7.5-13.5 hrs
    Insufflated 5-15 min 20-40 min 2-4 hrs 4-6 hrs 6-24 hrs 6.41-10.92 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.4
    Strong 6/10

    Strong anxiety/jitters and stimulation with moderate focus, mild euphoria

    Stimulation / Energy ×3
    9
    stimulation increased energy wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding bruxism vasoconstriction
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~28d

    Model reflects general stimulant patterns and self‑reports; exact kinetics unknown for 4C‑MAR.

    Cross-Tolerances

    other aminorexes
    amphetamine derivatives

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 4-Cl-MAR with another substance

    4-Cl-MAR's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Cl-MAR there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Cl-MAR (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Cl-MAR
    Unit
    mg
    Description 
    4-Cl-MAR
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 20-40 · light 40-80 · common 80-150 · strong 150-200 · heavy 200+
Insufflated dose (mg): threshold 10 · light 10-25 · common 25-50 · strong 50-80 · heavy 80+

Oral duration: onset 0.5-1.5h · come-up 1-2h · peak 2-4h · offset 4-6h · total 7.5-13.5h · after-effects 6-24h
Insufflated duration: onset 5-15m · come-up 20-40m · peak 2-4h · offset 4-6h · total 6.41-10.92h · after-effects 6-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 115 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.