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    Disclaimer
    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2C-T-4-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Nbome-2c-t-4

    Psychedelic Research-chemical

    Summary dose.wiki

    1. 2C-T-4-NBOMe is active in the microgram range; a milligram-scale error can be fatal. Always volumetrically dose with a 0.001 g-accurate scale.

    Dose Information Drugs.Wiki

    Dose basis. Ranges synthesized from user reports and class (NBOMe) guidance; extremely steep dose–response. Do not exceed 1,500 µg total per TripSit harm-reduction guidance. Volumetric dosing strongly advised. Anecdotal reports; similar to sublingual potency. Large interindividual variability typical for NBOMe series. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Sublingual 200-400µg 400-800µg 800-1200µg 1200µg+ (very risky)
    Buccal 250-450µg 450-900µg 900-1300µg 1300µg+
    Insufflated 100-250µg 250-600µg 600-1000µg 1000µg+ (severe body-load/vasoconstriction reports)
    Light Common Strong Heavy
    Sources

    Sublingual

    Dose ladder — Drugs.Wiki

    Buccal

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 10-30 min 30-60 min 1-3 hrs 4-6 hrs 2-6 hrs 5.67-10.5 hrs
    Buccal 10-30 min 30-60 min 1-3 hrs 4-6 hrs 2-6 hrs 5.67-10.5 hrs
    Insufflated 5-20 min 20-40 min 1-3 hrs 4-6 hrs 2-6 hrs 5.41-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.6
    Moderate+ 5/10

    Strong body load with moderate visuals, mild headspace and auditory effects

    Visual Intensity ×3
    7
    color enhancement drifting tracers pattern recognition enhancement
    Headspace Depth ×3
    4
    introspection recursive thought loops time distortion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea bodily discomfort temperature regulation suppression muscle tension teeth grinding increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Tolerance figures extrapolated from serotonergic psychedelic class behavior; specific 2C‑T‑4‑NBOMe data are lacking.

    Cross-Tolerances

    LSD
    Psilocybin
    Other serotonergic psychedelics

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Neutral

    Combinations

    Cross-Check 2C-T-4-NBOMe with another substance

    2C-T-4-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2C-T-4-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2C-T-4-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2C-T-4-NBOMe
    Unit
    µg
    Description 
    2C-T-4-NBOMe
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): threshold 100 · light 200-400 · common 400-800 · strong 800-1200 · heavy 1200+ (very risky)
Buccal dose (µg): threshold 100 · light 250-450 · common 450-900 · strong 900-1300 · heavy 1300+
Insufflated dose (µg): threshold 50 · light 100-250 · common 250-600 · strong 600-1000 · heavy 1000+ (severe body-load/vasoconstriction reports)

Sublingual duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 4-6h · total 5.67-10.5h · after-effects 2-6h
Buccal duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 4-6h · total 5.67-10.5h · after-effects 2-6h
Insufflated duration: onset 5-20m · come-up 20-40m · peak 1-3h · offset 4-6h · total 5.41-10h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 600 µg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.