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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2,5-DMA Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 30 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: Dma, Doh, 2,5-dimethoxyamphetamine

    Psychedelic Stimulant Research-chemical

    Summary dose.wiki PsychonautWiki

    2,5-DMA is a research chemical and the simplest member of the DOx family, primarily known as a precursor in synthesizing other psychedelic amphetamines rather than for its own psychoactive effects. Unlike typical psychedelics, it produces primarily stimulant and physical effects with minimal to no sensory or perceptual changes. Very little data exists about its pharmacology, metabolism, and toxicity.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-40mg 40-80mg 80-200mg 200mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.0
    Moderate 4/10

    Moderate visuals and body load with mild auditory effects, low headspace

    Visual Intensity ×3
    7
    color enhancement drifting tracers pattern recognition enhancement
    Headspace Depth ×3
    1
    time distortion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    6
    temperature regulation suppression muscle tension increased heart rate
    Stimulant 4.9
    Moderate+ 5/10

    Strong anxiety/jitters with moderate stimulation and euphoria, low focus

    Stimulation / Energy ×3
    7
    physical stimulation stimulation wakefulness
    Euphoria / Mood Lift ×2
    7
    cognitive euphoria euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia increased heart rate muscle tension tremors
    Based on reports from:
    PiHKAL PiHKAL #54: 2,5-DMA
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects dose.wiki PsychonautWiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 2,5-DMA with another substance

    PiHKAL / TiHKAL Shulgin

    PiHKAL #54: 2,5-DMA
    2,5-DMA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes 2,5-DMA, but its built-in data can be thinner than ours. Importing this file adds a separate "2,5-DMA (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "2,5-DMA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.