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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-TFMXP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 2-tfm-mxp

    Dissociative Research-chemical

    Summary dose.wiki

    2-TFMXP is the 2-trifluoromethyl analogue of methoxphenidine (MXP). Very little formal pharmacology is published; all dosing is extrapolated from user reports and structural activity relationships. Compared with MXP it appears 1.5-2× more potent and noticeably more stimulating with increased mania potential.

    Dose Information Drugs.Wiki

    Dose basis. All values are from user reports and class extrapolation; inter‑individual variability is high and the dose–response can be steep. Start low and allow a full onset before redosing. Bitter; can numb mouth. Reports suggest slightly higher bioavailability than swallowed. Expect delayed peak even if onset feels quick. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-45mg 45-70mg 70mg+ (NOT RECOMMENDED)
    Sublingual 8-20mg 20-40mg 40-60mg 60mg+ (NOT RECOMMENDED)
    Insufflated 5-15mg 15-30mg 30-45mg 45mg+ (NOT RECOMMENDED)
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Sublingual

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1.5-4 hrs 2-4 hrs 24 hrs 4.33-10 hrs
    Sublingual 10-30 min 20-45 min 1.5-4 hrs 2-4 hrs 24 hrs 4-9.25 hrs
    Insufflated 5-15 min 15-30 min 1.5-4 hrs 2-4 hrs 24 hrs 3.83-8.75 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.0
    Strong 6/10

    Strong dissociative depth and motor impairment with mild mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +3 more
    ⚠ Mania / Compulsion ×1
    4
    stimulation euphoria
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +1 more
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Acute tolerance builds rapidly over hours to days, similar to other NMDA antagonists. After multi‑day use, a partial tolerance can persist for 1–2 weeks and typically returns near baseline by 4–6 weeks if abstinent. Data are from class analogs and user reports rather than formal studies.

    Cross-Tolerances

    Ketamine
    MXP (methoxphenidine)
    3‑MeO‑PCP/O‑PCE (arylcyclohexylamines)
    DXM

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 2-TFMXP with another substance

    2-TFMXP's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-TFMXP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-TFMXP (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-TFMXP
    Unit
    mg
    Description 
    2-TFMXP
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5-10 · light 10-25 · common 25-45 · strong 45-70 · heavy 70+ (NOT RECOMMENDED)
Sublingual dose (mg): threshold 4-8 · light 8-20 · common 20-40 · strong 40-60 · heavy 60+ (NOT RECOMMENDED)
Insufflated dose (mg): threshold 3-5 · light 5-15 · common 15-30 · strong 30-45 · heavy 45+ (NOT RECOMMENDED)

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1.5-4h · offset 2-4h · total 4.33-10h · after-effects 24h
Sublingual duration: onset 10-30m · come-up 20-45m · peak 1.5-4h · offset 2-4h · total 4-9.25h · after-effects 24h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1.5-4h · offset 2-4h · total 3.83-8.75h · after-effects 24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 35 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.