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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Ortetamine, 2-methylamphetamine

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine, though higher doses can induce anxiety, vasoconstriction, and tremor.

    Dose Information dose.wiki Drugs.Wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 10-30mg 30-50mg 50-70mg 70mg+
    Light Common Strong Heavy
    Sources

    Insufflated

    Dose ladder — dose.wiki, Drugs.Wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-30 min 30-60 min 1-2.5 hrs 2-4 hrs 1-10 hrs 3.75-8 hrs
    Insufflated 5-15 min 15-30 min 1-2.5 hrs 2-4 hrs 1-10 hrs 3.33-7.25 hrs
    Rectal 3-10 min 10-20 min 1-2.5 hrs 2-4 hrs 1-10 hrs 3.22-7 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.4
    Moderate+ 5/10

    Strong anxiety/jitters and euphoria with mild stimulation and focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    euphoria cognitive euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate bruxism vasoconstriction sweating
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~30d

    Tolerance to stimulant effects tends to build quickly with consecutive-day use and decays over 1–6 weeks with abstinence; estimates are based on stimulant-class patterns and user reports (anecdotal). Avoid back-to-back days to keep tolerance lower and reduce compulsive redosing risk.

    Cross-Tolerances

    amphetamine
    methamphetamine
    cathinones
    other dopaminergic stimulants

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • Visual and auditory hallucinations
    • Closed/Open eye visuals

    Combinations

    Cross-Check 2-MA with another substance

    2-MA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-MA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-MA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-MA
    Unit
    mg
    Description 
    2-MA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5-10
Insufflated dose (mg): light 10-30 · common 30-50 · strong 50-70 · heavy 70+
Rectal dose (mg): threshold 5-10

Oral duration: onset 15-30m · come-up 0.5-1h · peak 1-2.5h · offset 2-4h · total 3.75-8h · after-effects 1-10h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2.5h · offset 2-4h · total 3.33-7.25h · after-effects 1-10h
Rectal duration: onset 3-10m · come-up 10-20m · peak 1-2.5h · offset 2-4h · total 3.22-7h · after-effects 1-10h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 40 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.