2-Chloroephenidine Stats & Data
2-cl-eph
2-cl-ephenidine
2-cl-diphenidine
2chloroephenidine
2clephenidine
2-chloro-ephenidine
PubChem
MW259.77
FormulaC16H18ClN
LogP4.3
IUPAC2-(2-chlorophenyl)-N-ethyl-1-phenylethanamine
InChIKey
CIZLUPKWIPWOID-UHFFFAOYSA-N
Chemical Class
Diarylethylamine
Psychoactive Class
Dissociative
Receptor Profile
Receptor Actions
Antagonists
NMDA receptor antagonist (noncompetitive)
Effect Profile
Curated
Dissociative
6.0
Strong dissociative depth and motor impairment with mild mania, low insight
Dissociative Depth×3
10
Mania / Compulsion×1
4
Insight / Novel Thought×2
3
Motor / Sensory Impairment×1
10
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
References
Cited References
- Bluelight: New dissociative RCs thread (2014-2015)
- Journal of Psychopharmacology - Pharmacological investigations of diphenidine analogues (2016)
- Nervewing: Diarylethylamines overview (2020)
- PiHKAL.info - 2-Chloroephenidine (IUPAC & molecular data)
- PLOS ONE - Pharmacological Investigations of Dissociative 'Legal Highs' (2016)
- PubChem: CID 43489092 - 2-Chloro-ephenidine
- TripSit: Factsheet - 2-Chloroephenidine
- UK ACMD - Diphenidine diarylethylamine review (2023)
- UK ACMD diarylethylamine report (2023)
- NCATS Inxight entry – 2-Chloro-ephenidine
- Bluelight: TR – 100 mg rectal 2-Cl-Eph (2015)
- Designing novel diarylethylamines overview (Bluelight, 2020)
- Pharmacological investigations of diphenidine analogues (J Psychopharmacol 2016)
- Receptor-binding heat-map of diarylethylamines (2016)
- Reddit: r/researchchemicals binding-affinity thread (2023)
- List of designer drugs – diarylethylamines
- Wiley NPS laboratory testing review (2023)
- Enantiomeric separation of diphenidine derivatives (J Chromatogr B 2025)
- Structure–activity summary of diarylethylamines (ResearchGate 2024)
- French Addictovigilance Network – phenidine complications (2019)
- PubChem: 2 Chloro ephenidine