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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1cP-MiPLA Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 30 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Psychedelic Research-chemical

    Summary dose.wiki PsychonautWiki

    1cP-MiPLA (1-cyclopropionyl-N-methyl-N-isopropyllysergamide) is a novel lysergamide first appearing on research chemical markets around 2020. It acts as a prodrug that rapidly hydrolyzes to MiPLA, similar to how 1P-LSD converts to LSD. Potency is approximately 60-80% of LSD by weight; many users find 150 ug comparable to 100 ug LSD.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Oral 100-150µg 150-200µg 200-250µg 300µg+
    Sublingual 100-150µg 150-200µg 200-250µg 300µg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Sublingual

    Dose ladder — Light–Heavy: same as the Oral row (dose.wiki, PsychonautWiki); no source states these Sublingual figures

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 45-90 min 1-2 hrs 1-2 hrs 2-6 hrs 3.08-6.17 hrs
    Sublingual 20-40 min 45-90 min 1-2 hrs 1-2 hrs 2-6 hrs 3.08-6.17 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 7.5
    Intense 8/10

    Strong visuals and auditory effects with moderate headspace and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers pattern recognition enhancement scenery slicing color shifting +3 more
    Headspace Depth ×3
    6
    conceptual thinking emotion enhancement thought loops time distortion
    Auditory Effects ×1
    8
    auditory distortion auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    6
    temperature regulation suppression nausea increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (lysergamide)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 5d Baseline ~14d

    Functional tolerance to lysergamides rises rapidly within a single session and decays over 5–14 days; acute redosing beyond ~45–60 min is typically inefficient. Cross‑tolerance is expected across serotonergic psychedelics that act via 5‑HT2A.

    Cross-Tolerances

    LSD
    Psilocybin/psilocin
    Other serotonergic psychedelics

    Effects dose.wiki PsychonautWiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 1cP-MiPLA with another substance

    1cP-MiPLA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has 1cP-MiPLA, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "1cP-MiPLA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Sublingualcommon ~ 175 µg
    Dose & duration (reference) 
    1cP-MiPLA: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): threshold 40ug · light 100-150 · common 150-200 · strong 200-250 · heavy 300+

Sublingual duration: onset 20-40m · come-up 0.75-1.5h · peak 1-2h · offset 1-2h · total 3.08-6.17h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.